Zinzino

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Regular price 199,00 €
Regular price Sale price 199,00 €

The gut microbiota influences everything from digestion and immunity to metabolism and mood. The gut health test reveals its functional output—what your gut bacteria are actually producing—and how that activity affects you.

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Zinzino

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This test focuses on three scientifically important compounds:

• Indole-3-propionic acid (IPA) (IPA level): a beneficial metabolite produced exclusively by gut bacteria from dietary tryptophan. Higher levels are linked to greater intestinal barrier integrity and protection against oxidative stress. IPA is increasingly recognized as a key indicator of gut microbiota function and overall resilience.

• Tryptophan (TRP): an essential amino acid obtained from the diet that serves as a precursor (starting material) for both IPA and kynurenine. Tryptophan availability and how it is metabolized can influence gut health, immune function, and metabolic balance.

• Kynurenine (KYN): a metabolite produced from tryptophan via the kynurenine pathway, often activated by increased immune stress. Higher kynurenine levels and an elevated KYN:TRP ratio are associated with increased immune activation and a shift in the production of beneficial microbial metabolites.

We also calculated these key ratios:

• IPA:TRP ratio (gut microbiome efficiency): reflects the proportion of dietary tryptophan converted by gut bacteria into IPA, influenced by the composition of the gut microbiota and diet.

• KYN:TRP ratio (immune stress indicator): an established marker of immune activation and burden.

• IPA:KYN ratio (microbiome immune support): a relative balance score that shows the relationship between protective and stress-driven pathways in tryptophan metabolism.

Their report also includes a gut health index, which integrates all the measured markers and ratios into a clear and easy-to-understand overview of your gut-immune-metabolic balance.

Why is tryptophan metabolism important?

Tryptophan metabolism is increasingly recognized as a critical connector of gut, immune, brain, and metabolic health. Gut bacteria transform tryptophan into a variety of indole metabolites, including IPA: a health-supporting metabolite that maintains intestinal barrier integrity, modulates immune responses, and helps protect against oxidative stress.

New research shows that higher levels of IPA are linked to metabolic flexibility, glucose regulation, and immune function. Conversely, when tryptophan metabolism is dysregulated, more of it is diverted to the kynurenine pathway—a pathway often triggered by your body's stress responses.

This metabolic crossroads between the body and gut bacteria is no longer a scientific curiosity; it is now considered a cornerstone of intestinal and systemic homeostasis. By decoding your tryptophan metabolism profile, this test reveals the functional performance of your gut bacteria and their relationship to immune and metabolic pathways, allowing you to make selective, evidence-based changes to support long-term health from the inside out.

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